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Energy, Age, & Estrogen

Energy, Age, & Estrogen

Dr. Alyssa Dweck discusses what’s really happening during menopause.

Dr. Alyssa Dweck discusses what’s really happening during menopause.

By Alyssa Dweck MS, MD, FACOG

Women who come into my office often ask me the same thing: How do some women age so gracefully? I tell them it is in part genetically determined, but that they can take a proactive role to optimize the process. The reality for most women is that well before the first menopausal symptom is experienced, a series of hormonal changes is already well underway. 

What’s Happening During Menopause

Menopause signals the end of the natural reproductive potential and declining hormone levels for women. You see, women are born with a full complement of eggs which are stored in and released by the ovaries on a monthly basis, in most cases. Typically, a well-orchestrated sequence of estrogen, progesterone, and testosterone (aka sex hormones) production occurs each month with ovulation. Over our lifespan, our ovaries age as we age. In other words, we do not produce more eggs over time. In fact, as ovaries age, ovulation becomes less frequent and eventually ceases. As such, these sex hormone levels start to fluctuate and eventually decline significantly. This can last for upwards of 10 years prior to the last menstrual cycle.  

It may come as a surprise that our brain, muscle, and fat cells all have hormone receptors, thus, these changes occur on a cellular level. In addition to the well-known vasomotor complaints associated with this transition, aka hot flashes and night sweats, other common but less-publicized symptoms are numerous. These include sleeplessness, fatigue, less energy, memory loss, poor concentration, weight gain, mood volatility, joint pains, imbalance, and yes, even a lower libido.  

While it is never too late, the sooner healthy lifestyle habits are initiated, the less dramatic and more positive this transition can be.

— DR. ALYSSA DWECK

Although the transition to menopause can take upwards of 10 years for some, the average age of menopause is 51. Menopause is defined as a full year without a period. While it is never too late, the sooner healthy lifestyle habits are initiated, the less dramatic and more positive this transition can be. 

Here are some helpful pearls to ease the menopausal transition and maximize energy at the same time.

You Age How You Eat

The Mediterranean diet emphasizes eating primarily plant-based foods including fruits and vegetables, whole grains, legumes, and nuts—all of which are helpful for controlling weight and preventing hot flashes. More importantly, this diet, rich in natural antioxidants, is encouraged for prevention of major chronic diseases such as heart disease and cancer, including breast cancer in women. The Mediterranean diet suggests limiting salt intake and replacing it with herbs and spices for flavor, which may reduce hypertension (high blood pressure), an independent risk factor for heart disease. 

The low glycemic index in a plant- and lean protein-based diet promotes stable insulin and glucose levels and helps to reduce hot flashes, often associated with a high sugar intake. Sugar highs and subsequent lows or “sugar crashes” are avoided on this diet. Healthy fats such as olive oil and canola oil, instead of butter, help promote a normal lipid profile including elevated HDL (good cholesterol) and lower LDL (bad cholesterol). The Mediterranean diet is also rich in complex carbohydrates, but devoid of simple ones, promoting satiety.

Caffeine, commonly found in coffee, black tea, and chocolate, should be consumed in moderation or avoided altogether, as excessive caffeine intake triggers hot flashes. Not only can caffeine prompt hot flashes, but it can also zap energy upon its withdrawal, contributing to the overall energy loss women feel during this transition.

Exercise Does More Than Keep You Fit

During menopause, lean body mass or muscle is naturally lost. In part, this is due to diminished ovarian production of testosterone. Testosterone naturally declines with age; the most rapid loss occurs during the perimenopausal transition. This leads to a lower metabolism, diminished lean body mass (muscle), and difficulty with weight control. Remember, muscle cells have testosterone receptors (a site on the surface of a cell that binds to and responds to testosterone). Less circulating testosterone means lowered lean body mass. This alteration occurs on a cellular level. 

Exercise, including cardio (running, elliptical, biking, swimming, walking) and weight training, are essential to build and maintain muscle mass and a strong metabolism, particularly with lower circulating testosterone levels.

Exercise, including cardio and weight training, are essential to build and maintain muscle mass and a strong metabolism, particularly with lower circulating testosterone levels.

— DR. ALYSSA DWECK

Stress A Little Over Your Stress Levels

Chronic stress spurs the hot flashes and night sweats of menopause, leads to weight gain around the middle, visceral (around internal organs) fat accumulation, and is generally unhealthy. This in part occurs since chronic stress leads to increased cortisol production by the adrenal glands (small glands that sit on top of the kidneys). This starts a cascade of events including increased insulin levels, plummeting glucose levels, increased dietary intake of carbohydrates, and eventual deposition of adipose tissue (fat), particularly around the waistline, aka the dreaded “muffin top” so many menopausal women struggle with. Remember, less stress means less cortisol secretion.

Stress reduction through exercise, yoga, meditation, and mindfulness exercises are vital to a healthy lifestyle. Many find these practices, even for short time spans first thing in the morning, promote energy and well-being throughout the day.

Start Now To Stay Healthy Later

It may seem overwhelming to commit to dietary and lifestyle changes, but here are some helpful hints to ease the transition. Avoid smoking and moderate alcohol intake to minimize uncomfortable vasomotor symptoms of menopause, lessen cancer risk, and maximize cardiovascular health. Both smoking and alcohol affect blood vessel tone. Smoking constricts blood vessels which increases blood pressure and skin temperature and decreases tissue oxygenation. Conversely, alcohol dilates blood vessels on the skin surface to dissipate heat. Both have effects on the blood vessels of the brain as well.

Regular sexual activity raises endorphins (the feel-good chemicals in the brain), diminishes stress, and promotes a general sense of well-being.

Many women are also deficient in vitamin D, which is vital for bone health, and provides numerous other health benefits. Ensure adequate levels of vitamin D with a simple blood test and supplement with vitamin D3 if levels are low. 

NAD Increases Energy Levels

NAD Increases Energy LevelsOn a cellular level, it’s important to note that levels of a molecule known as NAD also decline with age. NAD (nicotinamide adenine dinucleotide) is critical for mitochondria function. It fuels the cell's powerhouse and enhances cellular metabolism. Increasing NAD through supplementation may further boost energy levels before, during, and after the menopausal transition.

 

 

In my busy OB/GYN practice, I try to impress upon my patients that menopause can be and should be a liberating time rather than one of fear or dread. With age comes wisdom, freedom, and confidence. So, what is the secret to a smoother transition to menopause? I try to practice what I preach: commit to healthy lifestyle habits, maximize energy, and manage stress. With these principles and a little bit of genetic good luck, women can and should take an active role to embrace the aging process with grace and ease. Make it a priority!

 


ALYSSA DWECK, MS, MD, FACOG is a practicing gynecologist in Westchester County, New York and Assistant Clinical Professor in the Department of Obstetrics, Gynecology, and Reproductive Science at the Mount Sinai School of Medicine. As an author of three books, a Massachusetts General Hospital, Vincent Memorial OB/GYN Service consultant, and accomplished triathlete, Dr. Dweck offers her expertise across various platforms in an effort to destigmatize gynecologic issues and support women’s health across the country. She resides in Westchester County with her husband, their two sons, & their extraordinarily girly English bulldog.

How To Have A Healthy Brain: According To A Harvard Neurology Professor

How To Have A Healthy Brain: According To A Harvard Neurology Professor

Dr. Rudolph Tanzi discusses inflammation, microbiomes, and staying energetic as we age.

In effect, your brain brings you your world. But you have the power to determine the world your brain brings you.
— DR. RUDOLPH TANZI KENNEDY PROFESSOR OF NEUROLOGY, HARVARD MEDICAL SCHOOL

 

Dr. Rudolph Tanzi and Deepak Chopra recently published their third book called The Healing Self, and just the act of reading it feels like self-care. 

Their other two books, Super Brain and Super Genes, are about maximizing the potential already found in our minds and bodies. Tanzi and Chopra take that theory even further in The Healing Self, by encouraging a holistic approach to immunity. In this new goop interview, Dr. Tanzi talks about the research that inspired their new book, whether or not we can really control our brains, and the number one thing that goes wrong when we age: inflammation.

Read The Full Interview: “Rewire Your Head, Change Your World"

You can try to hit all the pathologies of aging, like inflammation, with lifestyle. But there’s no clear lifestyle way to hit energy, other than replenishing some of the natural molecules in the body that help provide energy.
— DR. RUDOLPH TANZI KENNEDY PROFESSOR OF NEUROLOGY, HARVARD MEDICAL SCHOOL

Rudolph Tanzi, PhD is the Joseph P. and Rose F. Kennedy Professor of Neurology at Harvard Medical School and vice-chair of Massachusetts General Hospital’s Neurology Department. His Alzheimer’s work landed him on Time magazine’s 100 Most Influential People list. As a proud vegetarian, he developed ways of studying Alzheimer’s disease without relying on mouse models. He currently lives in Boston where he continues to research, teach, and serve on a number of boards dedicated to healthy aging, including the ChromaDex Scientific Advisory Board.

What’s So Special About Nicotinamide Riboside?

What’s So Special About Nicotinamide Riboside?

An FAQ with Dr. Charles Brenner: The scientist who uncovered NR’s potential discusses why this nutrient is so unique. 

What’s So Special About Nicotinamide Riboside? Dr Charles Brenner

Q

How is NR different from the other B3s?

A

Nicotinamide riboside (NR), nicotinic acid (niacin), and nicotinamide are all “NAD precursors” meaning they can be used by cells to create more NAD. When supplemented at high doses, nicotinic acid causes the very uncomfortable side effect of flushing. High dose nicotinamide inhibits a class of enzymes called sirtuins that are associated with extended lifespan in model systems. In contrast, NR does not cause flushing and does not inhibit sirtuins. Moreover, studies in mice have shown that the NRK genes – which are necessary for converting NR into NAD – are active in neurons and all tissues and get turned up by conditions of metabolic stress. For example, in a failing mouse heart and a degenerating mouse neuron, the NRK pathway is activated, suggesting that NR is the preferred B3 when energy is low. [1, 2]

In summary, NR is a uniquely valuable form of vitamin B3 that increases NAD, the central regulator of metabolism. Because NAD is under attack in conditions of metabolic stress and aging, we take NR to age better and help cells resist the inevitable stresses of life.

Q

Some are proposing that another NAD boosting compound, nicotinamide mononucleotide (NMN), is equal to NR in health benefits. Please explain the difference between NR and NMN.

A

Currently there is no way to compare the health benefits of NMN and NR in humans. Multiple published clinical trials confirm that NR safely and effectively increases NAD in humans. [3-6] So far NMN’s only published trials are in rodents.

The molecular difference between NMN and NR is a chemical group called a phosphate. My research group discovered the nicotinamide riboside kinases, NRK1 and NRK2, in 2004. [7] NRK1 and NRK2 put the phosphate onto NR in order to form NMN. Then NMN is converted to NAD. Importantly, the enzymes that make NMN and NAD are inside cells. Compounds like NMN (with one phosphate), NAD (two phosphates), and NADP (three phosphates) cannot get into cells. The largest piece of NAD that can get into cells intact is NR. We and others have shown that NMN and NAD depend on conversion to NR, entry of NR to cells, and subsequent conversion to NMN and NAD inside cells. [2, 8–12] Thus, while there are some papers showing impressive effects of NMN, there’s no reason to go to the expense of putting the phosphate on when cells and tissues have to take the phosphate off in order for these compounds to be effective.

Q

Does pterostilbene help NR or are they two separate processes? Would you recommend taking pterostilbene together with Niagen?

A

Currently there is no evidence that pterostilbene adds any benefit to NR, and I cannot recommend its use by people.

Pterostilbene is a polyphenolic compound and like many other phytochemicals, it’s an antioxidant in small doses. However, it was shown in human clinical testing that pterostilbene elevates human low density lipoprotein cholesterol (LDL-C) at doses of 100 mg and 250 mg per day. [13] Another company has combined pterostilbene with NR with an assertion that pterostilbene activates sirtuin 1. However, their data show that at 50 mg and 100 mg of pterostilbene per day, their supplement also raises LDL-C. [14] Eating blueberries is fine—and you’ll get plenty of polyphenols from nuts, fruits and vegetables—but based on these observations of elevated LDL, I would not recommend pterostilbene as a supplement.

 


Dr. Charles Brenner is the Roy J. Carver Chair and Head of Biochemistry at the University of Iowa, founding co-director at the Iowa Obesity Initiative, and also serves as the Chief Scientific Advisor to ChromaDex. See his CV.  

SOURCES
1 DIGUET ET AL., 2018 | 2 VAUR ET AL., 2017 | 3 TRAMMELL ET AL., 2016 | 4 AIRHART ET AL., 2017 | 5 MARTENS ET AL., 2018 | 6 DOLLERUP ET AL., 2018 | 7 BIEGANOWSKI AND BRENNER, 2004 | 8 FLETCHER ET AL., 2017 | 9 GROZIO ET AL., 2013 | 10 NIKIFOROV ET AL., 2011 | 11 RATAJCZAK ET AL., 2016 | 12 SOCIALI ET AL., 2016 | 13 RICHE ET AL., 2014 | 14 DELLINGER ET AL., 2017