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The Science Behind the Discovery

NAD is as essential to our cells as food, water, and oxygen.
Shouldn’t we understand what it is?


Over 150 scientific articles have been published on our key ingredient, nicotinamide riboside, and its benefits since its discovery as an NAD booster in 2004. The number of nicotinamide riboside studies coming out each year is steadily increasing as scientists continue to uncover the potential of this remarkable nutrient.

Nicotinamide riboside (NR) articles on PubMed

Our Chief Scientific Advisor led the discovery

In 2004, our chief scientific advisor discovered that nicotinamide riboside (NR) could support healthy levels of a vital cellular resource. This resource is a central component in energy metabolism and is believed to play an important role supporting health and wellbeing. Although NR is a naturally-occurring vitamin in milk, it’s only found in trace amounts. Based on our patents and the established techniques of our parent company ChromaDex, NR was exclusively licensed and developed as NIAGEN®

NIAGEN® increases NAD*, a vital resource for cellular energy

NAD (or nicotinamide adenine dinucleotide) is a vital resource found in all living cells. We use it every day. After over 100 years of studying this molecule, researchers are publishing more articles about NAD than ever before. Now we know NAD isn’t a constant resource. Things like overeating, or drinking alcohol can stress our system and cause NAD to decline. Some scientists even think this NAD decline plays a major role in how we age.



Every cell in the body utilises NAD+ to carry out hundreds of crucial cellular reactions required for life. For this reason, NAD+ is often described as the “central control molecule” of metabolism for our cells. However, it’s only recently that scientists have begun to truly understand the importance of NAD+ and that it declines with age and under conditions of physiological stress.(1)

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NAD declines up to 50% between ages 40-60

Chart showing how NAD declines with age

Tru Niagen® increases NAD by 40–50% after 8 weeks

Chart displaying how TruNiagen increases NAD by 40-50% after 8 weeks
NIAGEN® has a remarkable ability to boost NAD in tissues that need it.

NIAGEN® by the numbers


8 Published Human Clinical Studies


20+ Owned and Licensed Patents


175 Research Collaborations