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Bulletproof's Dave Asprey Talks NAD With Dr. Charles Brenner

Bulletproof's Dave Asprey Talks NAD With Dr. Charles Brenner

Find out what our Chief Scientific Advisor and Bulletproof's CEO have in common.

 

Now, if you’re listening to this going why should I care, this is PhD level biochemistry. Here’s the deal. This is fundamental to you being alive.
— DAVE ASPREY, BULLETPROOF CEO

On the surface, Bulletproof's Dave Asprey and biochemist Dr. Charles Brenner couldn’t appear more different. But as this Bulletproof Radio episode proves, they share one very important belief in nicotinamide riboside (NR). Here they discuss their mutual ambition to live healthy longer, why they think the mitochondria could unlock that ambition, and what NAD has to do with it all. 

Food and air are coming in. Your body turns them into electrons via the Krebs cycle. Then, the electron has to be carried somewhere. You got NAD to do that.
— DAVE ASPREY, BULLETPROOF CEO

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Dr. Charles Brenner is the Roy J. Carver Chair and Head of Biochemistry at the University of Iowa, founding co-director at the Iowa Obesity Initiative, and also serves as the Chief Scientific Advisor to ChromaDex. See his CV.  

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Dave Asprey, founder of Bulletproof and author of New York Times bestseller The Bulletproof Diet, is a Silicon Valley investor and technology entrepreneur. He is the creator of the widely popular Bulletproof Coffee, and host of the #1 health podcast, Bulletproof Radio.

How We Know NAD Declines With Age?

How We Know NAD Declines With Age?

This clinical study got scientists thinking about NAD and healthy aging.

How We Know NAD Declines With Age

The Massudi article from 2012 is often cited when looking at the potential of nicotinamide adenine dinucleotide (NAD) to improve human health as we age. That’s because there’s a lot of promising research around the connection between lower NAD levels and the aging process as a whole.

Here are just a few of the reasons why teams like Massudi’s are interested in the effects of NAD levels on human health:

  • NAD levels decline by up to 50% in human skin tissue between the ages of 40–60
  • NAD depletion may play an important role in the aging process [1]
  • Preclinical studies show a correlation between lower NAD levels and some age-related health conditions
“A strong negative correlation was observed between NAD+ levels and age in both males and females.”
         — MASSUDI, H., ET AL., 2012

 

Read all the science and research surrounding NAD at: AboutNAD.com

New Promising Study For Blood Pressure & Cardiovascular Health

New Promising Study For Blood Pressure & Cardiovascular Health

CU Boulder clinical trial confirms nicotinamide riboside (NR) increases NAD levels and potentially improves heart health.

New Promising Study For Blood Pressure & Cardiovascular Health

Our results also provide initial insight into the effects of chronic NR supplementation on physiological function in humans, and suggest that, in particular, future clinical trials should further assess the potential benefits of NR for reducing blood pressure and arterial stiffness in this group.— MARTENS, C., ET AL., 2018

Here are just some reasons why researchers are using NR to study the effects of higher NAD levels on human health:

●      NAD activates the “longevity genes” known as sirtuins [1]

●      NAD is used to support healthy DNA and aging through PARP activation

●      NAD levels decline by up to 50% in humans between the ages of 40–60

●      NAD depletion may play an important role in the aging process [2] 

Like everything else, NAD declines with age. But metabolic stressors that require NAD such as smoking, alcohol consumption, overeating, and sun radiation can speed up that decline. 


THIS STUDY TOOK THE SCIENCE A STEP FURTHER BY NOTING THAT NR TRENDED TOWARDS INCREASING ATP, WHICH IS NEEDED TO CREATE CELLULAR ENERGY.

— DR. RUDOLPH TANZI, KENNEDY PROFESSOR OF NEUROLOGY AT HARVARD MEDICAL SCHOOL, AND LEADING ALZHEIMER'S RESEARCHER TIME 100 MOST INFLUENTIAL, 2015